ABOUT US 当院について

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今までなかった
0番目の居場所

ありそうでなかった、0番目の安心できるここちよさ
プライベートな空間で、心温まるおもてなしと
あなたに寄り添い、自分だけの美容や健康をみつけていける
また行きたいと思えるそんな居場所に

point 01

あなたの医療コンシェルジュ

すべてのスタッフがあたたかくお迎えし、
あなたの悩みに真摯に向き合います。
医療のプロとしてぴったりの治療法を提案します。

point 02

DOCTOR 医師紹介

医師

黒田　揮志夫
KURODA KISHIO

富山大学卒業後、順天堂大学心臓血管外科教室に入局し、心臓外科および血管外科、静脈瘤治療に従事。外科専門医を取得。医学博士号を取得後に、病理診断医も従事し、病理専門医を取得。外科や病理の診療を深める中で、医療課題に関心を持つようになる。

保有資格: 医師

医学博士

病理専門医

死体解剖資格

日本医師会認定産業医

経歴（ダイジェスト）

心不全・虚血性心疾患の外科/心エコー研究、ならびに病理・デジタル病理/AIの実装研究に従事。
国際学会・国内学会での発表 計12件（国際8・国内4）。AHA/USCAP/Pathology Visions ほかで発表、Travel/Best Poster Award受賞。
査読論文：筆頭著者3編（Pathol Int, World J Hypertens, Ann Thorac Cardiovasc Surg）／共著12編（Nat Commun, Am J Pathol, Histopathology, Virchows Arch ほか）。
著書（分担執筆）2冊。研究費（科研費・NEDO 等）複数採択（PI/共同研究者）。

学会発表

国際学会（抜粋・全8件）

American Heart Association Scientific Sessions（2015, Orlando）／大動脈弁置換術併施心室中隔心筋切除に関する心機能・予後。
USCAP Annual Meeting（2017, San Antonio）／生体弁早期劣化と免疫反応。
Pathology Visions 2018（San Diego）2演題：TBLB腺癌AI検出、リンパ節転移検出の二段階DL法（Travel Award・Best Poster Award）
USCAP Annual Meeting（2019, Washington D.C.）2演題：遠隔デジタルコンサルテーションの診断改善、腫瘍細胞量DLモデル検証。
Pulmonary Pathology Society（2019, Dubrovnik）／腫瘍細胞量評価の病理×DLワークフロー（口演）。
Pathology Visions 2019（Orlando）／HALO-AI®の臨床導入。

国内学会（全4件）

日本心不全学会（2014, 大阪）口演：術前LVEF低下と転帰。
ISHR（International Society for Heart Research）日本部会（2014, 名古屋）ポスター：AVR併用心筋切除（Travel Grant）。
心筋生検カンファレンス（2014, 名古屋）ポスター：生体弁早期劣化と免疫反応。
日本呼吸器学会（2019）口演：肺腺癌/扁平上皮癌のAI鑑別（Travel Award）。

パネルディスカッション

Digital Pathology & AI Congress Asia（2019, 東京）「病理AI活用の意義と障壁」パネリスト。

主要論文

筆頭著者（3編）

Pathol Int. 2008：限局性腹膜中皮腫（腸閉塞）の報告。
World J Hypertens. 2015：高血圧性心筋症の臨床的レビュー。
Ann Thorac Cardiovasc Surg. 2016：OPCAB（オフポンプCABG）の早期成績（日本最多症例施設）。

共著（代表・12編）

Nat Commun. 2019／2021（訂正）：肺腺癌の多領域エクソームによる発がん進化。
Am J Pathol. 2019：WSI二段階DLによるリンパ節転移検出。
Diagn Pathol. 2019：びまん性間質性肺疾患での冷凍生検と外科生検の整合性。
Transl Lung Cancer Res. 2020：デジタル病理とAIのレビュー（肺癌）。
PLOS ONE. 2021：IPFにおけるニンテダニブ有効性の組織学的因子。
Virchows Arch. 2022：WSI遠隔コンサルによる診断精度向上。
Histopathology. 2022：病理×DLによる腫瘍細胞量評価ワークフロー。
BMC Cancer. 2024：ALT/WDLの過剰診断に関する検討（MDM2/CDK4）。

著書（分担執筆）

『急性心不全の集中治療：ECUM/CHDF章』（中外医学社, 2016）
『間質性肺炎・肺線維症と関連疾患：外科/経気管支生検章』（南江堂, 2018）

研究費・助成

科研費（基盤C）共同研究者（2016–2019, 2020–2024）
科研費（基盤C）代表：肥大型心筋症の病態解明と診断アルゴリズム（2016–2019）
NEDO：半自律学習フレームワークと知識創出基盤（2019–2023, 共同研究者）
長崎大学助成：病理AI市場調査（2018, 代表）

原文フルリスト（講演・論文・書籍・研究費）を見る

LECTURES/PRESENTATIONS
NATIONAL, INTERNATIONAL MEETINGS

International:
● Kuroda K, Kato. SR. Concomitant septal myectomy can improve left ventricular and atrial function detected by 2D speckle echocardiography as well as long-term survival in patients undergoing aortic valve replacement with marked ventricular hypertrophy. American heart association Scientific Session. 2015, Nov. Orlamd, FL. Poster presentation.
● Kuroda K, Kato SR. Xenoimmune Response Can Elicit Early Postoperative Bioprothetic Valve Degeneration. United States & Canadian Academy of Pathology’s 106th Annual Meeting, 2017 Mar. San Antonio TX. Poster presentation.
● Furukawa T, Kuroda K, Fukuoka J. Verification of deep learning to detect adenocarcinoma in TBLB using HALO AI®. Pathology Visions 18. 2018 Nov. San Diego, CA. Poster presentation.
● Pham HHN, Futakuchi M, Furukawa T, Bychkov A, Kuroda K, Fukuoka J. Double steps of deep learning algorithm decrease error in detection of lymph node metastasis in lung cancer patient. Pathology Visions 18. 2018 Nov. Poster presentation. San Diego, CA. Poster presentation. (Travel award, Best poster award).
● Watanabe S, Kuroda K, Furusato B, Fujimura S, Niino D, Yao T, Itoh T, Aoyama H, Bychkov A, Tsuyama N, Mikami Y, Nagao T, Ikeda T, Fukushima N, Harada O, Kiyokawa T, Yoshimi N, Oda Y, Aishima S, Maeda I, Mori I, Yamanegi K, Tsuneyama K, Katoh R, Izumi M, Fukuoka J. Significant Improvement of Diagnosis by Remote Digital Consultation in Japan. United States & Canadian Academy of Pathology’s 108th Annual Meeting, 2019 Mar. Washington DC. Poster presentation.
● Furukawa T, Kuroda K, Fukuoka J. Verification of deep learning model to measure tumor cellularity in transbronchial biopsies of lung adenocarcinoma. United States & Canadian Academy of Pathology’s 108th Annual Meeting, 2019 Mar. Washington DC. Poster presentation.
● Furukawa T, Kuroda K, Fukuoka J. Implementation of deep learning model to the clinic by measuring tumor cellularity in transbronchial biopsies of lung adenocarcinoma. The 2019 Pulmonary Pathology Society Biennial Meeting. 2019 Jun. Dubrovnik, Croatia. Platform presentation.
● Sakamoto T, Furukawa T, Kuroda K, Zaizen Y, Kashima Y, Yoshikawa A, Fukuoka J. Implementation of deep learning, HALO-AI®, into routine clinic tumor cell count study. Pathology Vision 19. 2019 Oct. Orland, FL. Poster presentation.

National:
● Kuroda K. Preoperative Systolic Dysfunction as Reflected by Low Left Ventricular Ejection Fraction under 35% is Associated with Poor Outcome. Annual Scientific Meeting of the Japanese Heart Failure Society. 2014 Oct. Osaka, Japan. Oral presentation.
● Kuroda K. Concomitant Myectomy with Aortic Valve Replacement (AVR) in Patients with Outflow Obstruction. Annual meeting of the International Research for Heart Search Japan section. 2014 Nov. Nagoya, Japan. Poster presentation. (Travel grant)
● Kuroda K. Early degeneration of bioprosthetic valve can reflect immune-mediated inflammatory reaction? Annual meeting of the Cardiac Biopsy Conference. 2014 Nov. Nagoya, Japan. Poster presentation
● Furukawa T, Zaizen Y, Kuroda K, Soushi M, Fukuoka J. Validity of artificial intelligence in differentiating adenocarcinoma and squamous cell carcinoma of the lung. the 59th Annual Meeting of the Japanese Respiratory Society. 2019 Apr. Oral presentation. (Japanese) (Travel award)

PANEL DISSUCUSSIONS
● Recognizing Significance and Barriers of AI Usage in Pathology. 5th Digital Pathology and AI congress in Asia. 2019 Apr. Panelist. Tokyo, Japan.

HONORS and AWARDS:
● Travel grant of Annual meeting of the International Society for Cardiac Research 2014

PUBLICATIONS:
First author
● Kuroda K, Ishizawa S, Kudo T, Uotani H, Hosokawa A, Tanaka T, Kitano H, Hori T, Tsukada K, Sugiyama T, Fukuoka J: Localized malignant mesenteric mesothelioma causing small bowel obstruction. Pathol Int. 2008 Apr; 58(4):239-43
● Kuroda K, Kato TS, Amano A. Hypertensive cardiomyopathy: A clinical approach and literature review. Hypertensive cardiomyopathy: A clinical approach and literature review. World J Hypertens 2015; 5(2): 41-52
● Kuroda K, Kato TS, Kuwaki K, Kajimoto K, Lee SL, Yamamoto T, Amano A. Early Postoperative Outcome of Off-Pump Coronary Artery Bypass Grafting: A Report from the Highest-Volume Center in Japan. Ann Thorac Cardiovasc Surg. 2016 Apr 20;22(2):98-107.

Co-Author
● Pham HHN, Futakuchi M, Bychkov A, Furukawa T, Kuroda K, Fukuoka J: Detection of lung cancer lymph node metastases from whole-slide histopathological images using a two-step deep learning approach. Am J Pathol. 2019 Sep 18. S0002-9440(19)30718-7.
● Hu X, Fujimoto J, Ying L, Fukuoka J, Ashizawa K, Sun W, Reuben A, Chow CW, McGranahan N, Chen R, Hu J, Godoy MC, Tabata K, Kuroda K, Shi L, Li J, Behrens C, Parra ER, Little LD, Gumbs C, Mao X, Song X, Tippen S, Thornton RL, Kadara H, Scheet P, Roarty E, Ostrin EJ, Wang X, Carter BW, Antonoff MB, Zhang J, Vaporciyan AA, Pass H, Swisher SG, Heymach JV, Lee JJ, Wistuba II, Hong WK, Futreal PA, Su D, Zhang J: Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma. Nat Commun. 2019 Jul 5;10(1):2978.
● Uegami W, Kuroda K, Furukawa T, Fukuoka J. 【Utilization of AI in medical care】Artificial intelligence in pathological diagnosis. Seikei-Saigai igaku. 2019 Mar. 62(3) 235-241 (Japanese).
● Furukawa T, Zaizen Y, Kuroda K, Soushi M, Fukuoka J. Validity of artificial intelligence in differentiating adenocarcinoma and squamous cell carcinoma of the lung. Nihon Kokyuuki Gakkai-shi. 2019 Mar. 8(supp) 210-210 (Japanese).
● Aikawa E, Shimizu T, Koga T, Endo Y, Umeda M, Hori T, Irie J, Kuroda K, Eguchi M, Okamoto M, Tsuji S, Takatani A, Igawa T, Sumiyoshi R, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Kawakami A. Atypical Familial Mediterranean Fever Complicated with Gastrointestinal Amyloidosis Diagnosed due to Paroxysmal Arthralgia and Intractable Diarrhea, Successfully Treated with Tocilizumab. Intern Med. 2019 Jun 15;58(12):1781-1785. doi: 10.2169/internalmedicine.2277-18. Epub 2019 Feb 1. PMID: 30713308
● Zaizen Y, Kohashi Y, Kuroda K, Tabata K, Kitamura Y, Hebisawa A, Saito Y, Fukuoka J. Concordance between sequential transbronchial lung cryobiopsy and surgical lung biopsy in patients with diffuse interstitial lung disease. Diagn Pathol. 2019 Dec 4;14(1):131. doi: 10.1186/s13000-019-0908-z. PMID: 31801596
● Sakamoto T, Furukawa T, Lami K, Pham HHN, Uegami W, Kuroda K, Kawai M, Sakanashi H, Cooper LAD, Bychkov A, Fukuoka J. A narrative review of digital pathology and artificial intelligence: focusing on lung cancer. Transl Lung Cancer Res. 2020 Oct;9(5):2255-2276. doi: 10.21037/tlcr-20-591. PMID: 33209648
● Nemoto M, Zaizen Y, Kataoka K, Kuroda K, Tabata K, Bychkov A, Sumikawa H, Johkoh T, Aoshima M, Kondoh Y, Fukuoka J. Histologic factors associated with nintedanib efficacy in patients with idiopathic pulmonary fibrosis. PLoS One. 2021 Jan 7;16(1):e0245147. doi: 10.1371/journal.pone.0245147. eCollection 2021. PMID: 33411718
● Hu X, Fujimoto J, Ying L, Fukuoka J, Ashizawa K, Sun W, Reuben A, Chow CW, McGranahan N, Chen R, Hu J, Godoy MC, Tabata K, Kuroda K, Shi L, Li J, Behrens C, Parra ER, Little LD, Gumbs C, Mao X, Song X, Tippen S, Thornton RL, Kadara H, Scheet P, Roarty E, Ostrin EJ, Wang X, Carter BW, Antonoff MB, Zhang J, Vaporciyan AA, Pass H, Swisher SG, Heymach JV, Lee JJ, Wistuba II, Hong WK, Futreal PA, Su D, Zhang J. Author Correction: Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma. Nat Commun. 2021 May 12;12(1):2888. doi: 10.1038/s41467-021-23163-3. PMID: 33980839
● Ota K, Takahashi T, Mitsui J, Kuroda K, Hiraoka K, Kawai K. A case of discrepancy between three ERA tests in a woman with repeated implantation failure complicated by chronic endometritis. BMC Pregnancy Childbirth. 2022 Dec 1;22(1):891. doi: 10.1186/s12884-022-05241-6. PMID: 36456975
● Sakamoto T, Furukawa T, Pham HHN, Kuroda K, Tabata K, Kashima Y, Okoshi EN, Morimoto S, Bychkov A, Fukuoka J. A collaborative workflow between pathologists and deep learning for the evaluation of tumour cellularity in lung adenocarcinoma. Histopathology. 2022 Dec;81(6):758-769. doi: 10.1111/his.14779. Epub 2022 Sep 12. PMID: 35989443
● Shinohara S, Bychkov A, Munkhdelger J, Kuroda K, Yoon HS, Fujimura S, Tabata K, Furusato B, Niino D, Morimoto S, Yao T, Itoh T, Aoyama H, Tsuyama N, Mikami Y, Nagao T, Ikeda T, Fukushima N, Harada O, Kiyokawa T, Yoshimi N, Aishima S, Maeda I, Mori I, Yamanegi K, Tsuneyama K, Katoh R, Izumi M, Oda Y, Fukuoka J. Substantial improvement of histopathological diagnosis by whole-slide image-based remote consultation. Virchows Arch. 2022 Aug;481(2):295-305. doi: 10.1007/s00428-022-03327-2. Epub 2022 Jun 7. PMID: 35672584
● Nomura K, Tomita M, Kuroda K, Souda M, Chiba K, Yonekura A, Osaki M. Overdiagnosis of atypical lipomatous tumors/well-differentiated liposarcomas by morphological diagnosis using only HE stained specimens: a case-control study with MDM2/CDK4 immunostaining and MDM2/CDK4 fluorescence in situ hybridization. BMC Cancer. 2024 Nov 21;24(1):1437. doi: 10.1186/s12885-024-13215-4. PMID: 39574032

BOOKS
● Kuroda K, Kato. SR. Emergency intensive care management for acute heart failure. Chapter of ECUM, CHDF. Chugai-igakusha. 2016 Mar. ISBN:4498136381 (Japanese)
● Kuroda K, Fukuoka J. Interstitial pneumonia・pulmonary fibrosis and related diseases. Chapter of surgical biopsy and trans-bronchial biopsy. 2018 Sep. ISBN: 978-4-521-74528-2 (Japanese)

FUNDING INFORMATON
2020 - 2024
● Grant-in-Aid for Scientific Research (C). Investigator ($48,100/total)
2019 - 2023
● Semi-self-learning framework and information infrastructure for creating knowledge. Grant of New Energy and Industrial Technology Development Organization. Investigator ($300,000/year)
The major goal of the study is to use semi-self-learning framework for pathology diagnosis.
2018
● Pathological diagnosis AI market research. Grant of Nagasaki University. PI ($8,000). The major goal of the study is to do market research of pathological AI
2016-2019
● Risk management of heart failure by combined use of myocardial serum microRNA and echocardiographic hemodynamic index. Grant-in-Aid for Scientific Research (C). Investigator ($48,100/total)
● Elucidation of pathophysiology of hypertrophic cardiomyopathy and creation of diagnostic treatment algorithm. Grant-in-Aid for Scientific Research (C). PI ($46,800/total)